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The Nobel Prize that Wasn’t

A week after the Nobel Prize went to Robert Edwards for his accomplishments in developing in vitro fertilization as a treatment for infertility—and more than thirty years after Edwards’ first successful IVF procedure in 1978—IVF still looks like an amateur lab experiment. The same ethical matters that troubled science when Edwards created his first test-tube baby remain unresolved, even in the wake of winning the world’s most prestigious prize.

Aimed at creating fertilized embryos, IVF destroys many more than it creates. Aimed at producing successful pregnancies, IVF results in twice as many failed attempts as successes. Aimed at healing the traumatic experience of infertility for many women, IVF brings with it a multitude of traumatic experiences for women—including years of failed attempts, miscarriages, and the difficult choice of which baby to abort when a prospective mother finds she has conceived more embryos than she could bring to term.

As the Nobel website itself clearly states: with IVF, “20-30 percent of fertilized eggs lead to the birth of a child.”

Yes, that means that for nearly one in every three couples, IVF can bring a much-wished-for child into the world. No one can deny that babies are priceless, and, for infertile women especially, it means the world just got better, to finally have a baby of one’s own. Studies have shown that the depression many women experience from infertility is similar to that experienced by people with heart disease or cancer. Sure IVF brings a rocky road of hormones and failed attempts, but the relief and joy that comes with the baby can make it all seem worth the costs.

So certainly a discovery that relieves women of the burden of infertility is worthy of a Nobel prize, right? Right.

But that’s not what Edwards’ development of IVF has achieved. IVF hasn’t cured infertility. If it had, all women who undergo IVF would no longer be infertile. Instead, Edwards has developed a procedure that costs more than $10,000 and rarely is covered by insurance, that comes with significant physical suffering, risks, and psychological burdens of its own, and that is marketed as the only option available to thousands of vulnerable, infertile women today—even though it offers no guarantee of success, and comes with a two-to-one risk of failure.

Of course, it has grown increasingly difficult to criticize IVF, because many of us now know a child who was conceived with IVF; and who could suggest that child shouldn’t be alive? To do so would be truly wrong. No other medical innovation has ever led so directly to the creation of human life. This represents a real, seemingly prize-worthy breakthrough in the history of medicine.

But, like most medical breakthroughs, it comes with a host of ethical ramifications. Even if we put aside the issue of what it means to be able to create people for whatever use we’d like—which is indeed ethically worrisome—there are other, equally troubling costs we can measure. For instance, we know IVF destroys many embryos in the process of seeking to bring one embryo to term. Doesn’t this matter just as much to medical practitioners as the creation of life?

Well, let’s consider that while looking at a recent example of scientific research. Last Friday we heard the horrifying report that during the 1940s American researchers in Guatemala willfully infected hundreds of people with STDs in an effort to find out if penicillin could be used to stop the spread of STDs. This is obviously an ethical and scientific disaster on the face of it; just last week President Obama publicly apologized for this decades-old scandal, since the U.S. government is responsible for funding the research.

Imagine if researchers found a cure for AIDS today; what an amazing achievement that would be! But if, in the process of reaching that cure, researchers infected several participants with AIDS, it would be not praiseworthy but abhorrent. Here’s the difference: The ethical scientist who discovered a cure for AIDS would win a Nobel Prize in Medicine; but the other one—who discovered a cure by using unethical procedures—it would be the journalist who blew the whistle on him who would win the Pulitzer Prize.

With science, as with everything, how we do something is just as important as the result we’re hoping to reach. It’s not okay to find cures to diseases by testing on voiceless people in developing countries. And, as Alfred Nobel well knew, it’s not justifiable to create peace in one place by bombing civilians in another. No matter how worthy a goal, it’s not legitimate to try to achieve peace at any cost. As humans, we are bound by reason and ethics to be humane.

With IVF, the worthy desire to help infertile couples conceive a baby can be so great that it can be tempting to overlook the ethical and human costs: the embryos destroyed in the process that are just as human as the ones created alongside them that come to full term and walk among us; the years of pain and struggle that many women undergoing IVF experience with the assurance that it will lead to a child, when often it doesn’t.

And that is why this year’s Nobel Prize for the discovery of IVF represents a failure. It fails humanity because it overlooks the human costs of IVF; it fails women because it overlooks their suffering that, even thirty years later, is still routine in the procedure; it fails science because it does nothing to encourage ingenuity and research for better treatments to the condition of infertility; and, in perhaps its greatest irony, it fails the legacy of the Nobel Prize itself.

Mary Rose Somarriba is managing editor of First Things.

Comments:

10.15.2010 | 11:07am
Mike M. says:
Abortion destroys babies. IVF produces babies.
10.15.2010 | 11:44am
pentamom says:
And then destroys the majority of them.
10.15.2010 | 11:45am
Jean-Baptist says:
Abortion destroys babies. IVF destroys embryos. Mike M. destroys logic...
10.15.2010 | 12:30pm
Mike M. says:
This exchange reminds me of a story from my father. When he was at university in the 1920's there was a widespread notion that lighting for reading should come from behind the left shoulder. This was debated and the presenter gave a long speech on the physics of light. His opponent then took the podium, said "The right eye needs as much light as the left eye" and then sat down. You can guess who won the debate. Illogical? Perhaps. But sometimes the shorter statement disperses the fog of sophistry.
10.15.2010 | 12:59pm
Lor says:
"Abortion destroys babies. IVF produces babies." -Mike M.

That's about as ethically illuminating as saying "slavery produced cotton."
10.15.2010 | 1:39pm
pentamom says:
Mike,I'm not grasping your point. Is there some scientific inaccuracy to the belief that most of the embryos created in IVF are destroyed? Was the Nobel website wrong that only 20-30% of embryos survive the process?

If not, my point is not dispelled with a simple scientific statement. Your dispute is based on the premise that some humans aren't human until some arbitrary point. Or maybe, your contention is that no amount of destruction is worth worrying about if the end result is some number of births. You're free to hold whatever ethical or philosophical positions you like on those things, but don't confuse them with simple scientific logic.
10.15.2010 | 1:54pm
Bob G says:
This Mike M is a doctor and comments on all items having to do with medicine. He affects to be skeptical, on the basis of his medical experience, of most Catholic doctrine on such matters, including abortion. He presents himself as a realist yet continues to be interested in what FT has to say on such matters. My guess is that he's struggling with his faith and with putting together what he sees as two different worlds. He will always present a counter-argument to what the Church teaches but he seems sincere i his way.
10.15.2010 | 2:01pm
GL says:
"Sulva is she whom mortals call the Moon. . . . There dwell an accursed people, full of pride and lust. . . . Their real children they fabricate by vile arts in a secret place."

C.S. Lewis, "That Hideous Strength"
10.15.2010 | 2:07pm
Jean-Baptist says:
Therefore, in your estimate Mark M., I lost the debate by three words and an initial. I'm humbled and intimidated in the presence of such superior arguments. Next time someone responds to my first comment I too will reply with an anecdote. That would be much better than responding to Ms Somarriba's points concerning the destruction of human embryos and women's psychological suffering.
10.15.2010 | 2:22pm
Mike M. says:
Bob G, You have astonishing insight. Thanks for you comment. Mike
10.15.2010 | 2:37pm
Bob G says:
Mike, what I said might be obvious to anyone paying attention. I don't envy your situation but admire your willingness to grapple with it. My feeling is that you have a good heart--and a hell of a lot more experience in these matters than I. I will pray that you find your way home. Good luck!
10.15.2010 | 6:21pm
Russell K says:
What the article obscures is that only 20 to 30% of eggs naturally fertilized in the womb survive that process, too.

In other words, the vast majority of fertilized eggs are not viable human beings, and discard themselves by failing to mature to embryos, failing to attach to the wall of the womb, or by miscarrying very early.

We don't know about those, because the mother doesn't even know it's going on. Nature does with natural fertilization what it does with IVF. With IVF we just happen to be watching it through a microscope. But it's still nature that does the choosing.

The ethical problem with IVF comes when multiple VIABLE embryos result from the process. If more than 2 or 3 are implanted, bringing them all to term will be problematic. Will the extras be aborted. Clearly, that would be a moral failure.

The extras can be frozen, but will the couple choose to have those thawed and implanted later, or just discard them? Discarding the extras would also be a moral failure, similar to abortion.

I'm not a doctor, but have 2 sons, thanks to IVF.
10.15.2010 | 6:43pm
Fiona says:
Wow! That is such fantastic news, so much hope for so many couples. 20-30% of IVF cycles result in babies. Compared to 0% of natural cycles for infertile couples. Fantastic.
10.15.2010 | 7:30pm
Thanks for your take on this, Ms. Somarriba. The Economist ran a piece that I think reflects what the libertine establishment thinks: " . . . in 1978, was [born] Louise Brown, the first of [four million test-tube babies]. Dr Edwards [was]accused at the time of playing God, being like ... Frankenstein ... Even today, there was a similar reaction from the Vatican ... The objection seems to be that not all embryos created by IVF are then implanted and brought to term. Some people, it seems, put more value on insentient balls of cells than on the full-grown human beings who would not have been born without Dr Edwards’s insight and persistence. Maybe they should meet Miss Brown . . ."

The view of the Magisterium is easy for libertines to deride. But I am (naively, perhaps) surprised at the ludicrous way they justify the manufacture of embyos—unique human offspring, which if allowed to follow their natural course can be anticipated to mature to whatever arbitrary degree one may choose recognize as human. And the author seems blind to the tens of millions of "could have beens" that "were not" due to the obscene spread of abortion.

As you point out, those born of this process were only one of many siblings that the process created and destroyed. They are obviously God's children—as was King Solomon, despite his origin, and even the most amoral libertines, despite their ultimate destinies, which only God knows—but, as mentioned by GL, the process (reflecting, I think, a profound unwillingness to accept God's will) does remind one of C.S. Lewis' story, or of (Tolkien's) Saruman and his creation of the uruk-hai.

Scientists derive often very substantial advantage, as in the case at hand, by cutting corners and ignoring morality (as we all may do at times), but very often at terrible cost, to society and to their own souls.
10.15.2010 | 9:33pm
Mike M. says:
Russell K, Thanks for being a father to your two sons who were brought into the world by IVF. They are much more precious than some here would have you believe. (Children fabricated by vile arts in a secret place by the libertine establishment). Such hateful talk for a religious site.
10.15.2010 | 9:52pm
ria says:
I think it's important to note that the way IVF is handled is directly related to money. If, like in Britain, IVF is a procedure covered by insurance, doctors can implant only 1 embryo at a time because the woman gets 3 tries. In the US, doctors are pushed to implant many embryos because it's expensive and most couples cannot afford to try a $10,000+ procedure several times.

IVF technology has much potential for good, as the author writes. It's just one cure for several types of infertility. Calling it a failure is incorrect. IVF can be used within much more ethical bounds than it is currently used today in the US. How the technology is implemented is a gray area and the government has left regulation up to private interests....which of course will be mostly interested in money.
10.15.2010 | 10:03pm
Mike Linton says:
Dear Mary: Thanks for this wonderful post; the irony of the prize. Wow. You nailed it. But thank you also for reminding us of that Guatemala business. It was horrifying and made more so by what some German researchers were doing at about the same time. But is there a word more shrill than “horrifying?” “Super-duper really awful horrifying” perhaps? Because if so, I need to use it for this: the fact that apparently we think that President Obama’s public apology is enough. No one is apparently being prosecuted for this. No one will spend the rest of his or her life in prison for this (and you can make a bet that not every one who was part of this research team is dead). Susan Revergy discovered the Guatemala experiments by accident, just as the radiation experiments carried out on unsuspecting people by the Manhattan Project were discovered by accident by Eileen Welsome (and for which her Plutonium Files won a Pulitzer in 1994). How many more bits of miserable research are out there to be discovered by dogged and dedicated researchers? I bet there’s more. And about those assurances of the Presidential Commission for the Study of Bioethical Issues that they will form a panel of international experts to "ensure that all human medical research conducted around the globe today meets rigorous ethical standards." Around the globe? What, a US commission is going to police what kind of experiments the Chinese, or Koreans, or Brazilians are doing? Yeah, right. And about those “international experts”, maybe they can be Nobel Prize winners perhaps?
10.15.2010 | 11:27pm
Hopefully, I can bring another perspective to this conversation. IVF is not only unethical (in my opinion, and the opinion of the Catholic Church), but it is unnecessary. Dr. Thomas Hilgers at Creighton University in Omaha, Neb. has, over the past 30 years, developed a new female health science called Naprotechnology. Naprotechnology (natural procreative technology) uses a variation of the Billings method of natural family planning (the Creighton Model Fertility Care System) and the latest in medical treatments to find the cause of infertility and treat it. It's success rate in achieving a pregnancy in infertile couples is around 75% (over 4-5 years, and 40% in the first year)----actually better than IVF. Addionally, Naprotechnology discovers the underlying cause of infertility and treats it----resulting in significant health benefits for the woman even after pregnancy. Dr. Hilger's methods are all in compliance with Catholic moral teaching. He continues to train other Napro physicians at the Pope Paul VI Institute in Omaha. Creighton Model physicians can now be found thoughout the U.S. and in many foreign counries. Sadly, his methods are not more widely known because of the predjudice of the Ob-Gyn academic community who refuse to acknowledge his accomplishments, or even study his methods due to their distaste for any science that has a connectiion to religion in general, or the Catholic Church, in particular. I became a Creighton Model physician in 2006. You can find out more informatioin on this truly exciting new science by going to www.creightonmodel.com.
10.16.2010 | 1:18am
txw says:
The extra embryo's in IVF do not die off randomly or "naturally". A deliberate reduction takes place, and so to equate this with a natural death of an embryo by miscarriage is a false opposition. (Plus Dr. Hilger's research has questioned the high miscarriage rate that we all been told. Roughly 30% of pregnancies miscarry before 12 weeks is what I had always been told, but it probably isn't that high, not that it matters much in the ends-means club.)
Good can come out of an evil act. The cotton in your underwear was grown on soil tilled by slaves 200 years ago. Please do not accuse this site of hateful talk, there was not a drop in the original post, just arguments.
IVF kids alive today have siblings not of this world, and most every IVF parent has more children awaiting in the next life.
10.16.2010 | 9:32am
Thank you to Dr. Michael Wulfers for making readers aware that a medical solution protective of women and human embryos and consistent with Catholic teaching now exists. And thank you also to Russel K. who explains a way in which IVF can be made acceptable to people of good will who are not Catholic (if I understand his meaning correctly that no embryos will be destroyed). His position is, if I am not mistaken, consistent with that of the Orthodox Jews.
10.16.2010 | 10:11am
GL says:
" Mike M. says:
Russell K, Thanks for being a father to your two sons who were brought into the world by IVF. They are much more precious than some here would have you believe. (Children fabricated by vile arts in a secret place by the libertine establishment). Such hateful talk for a religious site.'

First, I was quoting C.S. Lewis. Liberal Christians who admire Lewis must come to understand that he opposed their agenda.

Second, the ends do not justify the means. No one here believes Russell K's sons are anything other than children made in the image of God. Their existence is no less valued than anyone elses. That, however, does not justify IVF, any more than it justifies fornication, adultery or rape, all of which can and have resulted in the procreation of children made in the image of God and all of which, undoubtedly, have resulted in many of our own ancestors, just as it did our Lord's human ancestors. That David's adultery with Bathsheba led to the birth of Solomon and, later, Nathan, both direct ancestors of our Lord, does not justify David's act of adultery. Let's not confuse the issues.
10.16.2010 | 10:28am
pentamom says:
"They are much more precious than some here would have you believe."

EVERY child is precious. That is exactly the point. The ones lost in the process are as precious as the ones who survive, so it's hard to justify the expected and intended loss of some of the little ones, by the survival and flourishing of others.

And yet, even though the surviving children themselves are precious, it is still possible that the means by which they are brought into the world cause moral harm. Truly, the outcome (even an outcome as good as the birth of healthy, loved children) does not justify the means. Is that hard to grasp, or is this situation somehow an exception to that principle?

If someone were to solve their infertility problem by raping someone else, would it lessen the value of the life of the child born if we were to speak of the rape in the ugly language it deserves? I am not "equating" IVF with rape; I am simply pointing out that speaking of a morally suspect process in accurate but negative language does not devalue anyone's life, it simply places an accurate moral perspective on the process itself.
10.16.2010 | 11:16am
Jacob says:
Mike M. must still be busy preparing his snarky response.

Imagine if our lives were so desperate that we went on the websites that turn his crankshaft and critiqued what they say...not that many of us would have the stomach for such pursuits.


IVF kids are absolutely priceless as they are children of God.
Survivors of abortion or other forms of attempted murder are absolutely priceless as they are children of God.
10.16.2010 | 11:23am
Jacob says:
Also I Googled this for Mike M.:

Description of Hasty Generalization

This fallacy is committed when a person draws a conclusion about a population based on a sample that is not large enough. It has the following form:

1. Sample S, which is too small, is taken from population P.
2. Conclusion C is drawn about Population P based on S.
10.16.2010 | 11:42am
Mike M. says:
Dr. Wulfers, I have searched the Creighton Model site and the next several dozen sites thrown up by Google and can find no unfavorable comments. As an Internist I am unfamiliar with this field but you bring good news. Why does the Ob-Gyn academic community object and what is their problem with religion? I know of no such prejudice in our American College of Physicians, though I could be wrong.
10.16.2010 | 2:03pm
Mike M says:
Jacob, Thanks for the constructive criticism. I accept it. And thanks also for the note on Hasty Genereralization. I see your point about that and stand corrected.
10.16.2010 | 2:30pm
Stuart Koehl says:
Human in vitro fertilization may be morally reprehensible, but animal in vitro is rapidly becoming a mainstay of animal husbandry, both for agricultural purposes and as a means of preserving endangered species.
10.16.2010 | 11:26pm
Dr. Mike M:

I can only speculate why the mainstream medical community has not been interested in Dr. Hilger's research. One reason is ignorance about modern NFP. Old methods of NFP, such as the rythmn method were not effective. I was not taught about fertility awareness systems in medical school, and contemporary students I have spoken with also know very little about fertility awareness methods. Secondly, as I mentioned in my previous post, there is a tendency in academia to scoff at anything in any way connected with religion. The Creighton Model is not exclusively for Catholics, but NFP is strongly associated with the Catholic church. Additionally, Dr. Hilgers is a devout, orthodox Catholic physician (He named his research institute after Pope Paul VI, in honor of Humane Vitae) Last, but not least, there is big money to be made in the IVF clinics. The current tendency among infertility specialists is, unfortunately, to do a cursory investigation of the causes of infertility and, then to proceed swiftly to IVF. There is, I believe, a little bit of arrogance involved here. Why should we (Reproductive Medicine specialists) bother with trying to fix what's wrong with a woman's reproductive system-----we can just make a baby ourselves in our petri dishes! Again, the above is just speculation. Eventually, some of the academics will start to test out and try to reproduce some of Hilger's work. Woman's health will be better when that happens----naprotechnology can treat many conditions other than infertility, such as irregular cycles, PCOS, PMS, abnormal bleeding, ovarian cysts, etc.
10.17.2010 | 1:57pm
Leila says:
This critique of IVF is much needed and I appreciate the care with which the argument is made.

IVF has become mainstream, and no one grapples with the moral damage done to those who undergo it.

But even if IVF could be rid of its embryo-destroying aspect (and I don't see any incentive for that at present), it would still be wrong.

It's wrong to conceive a baby outside of the mother's womb.

Even a great longing for a child can't justify bringing it to life this way. There are many desires man has that can't be fulfilled. That's just our human condition.
10.21.2010 | 3:45pm
Audrey says:
In my experience, the reason healthcare providers are against FAM and NFP is because it is incompatible with being on the Pill. You can't be on the Pill and use FAM or NFP. And the Pill has to be one of the biggest money makers for the drug industry, and my understanding is that doctors who prescribe it (and any other drug) get lots of benefits from drug reps. Given that over 90% of women will at some point in their lives use the Pill, this is a huge enterprise for the medical establishment.

Also, many doctors are sold (no pun intended) on the idea that the Pill is a panacea for just about any ailment that afflicts women. During a routine gyn visit, I was brow-beaten by the doc for NOT being on the pill. I was given a rather uncomfortable exam following our exchange, during which she became so upset she had to leave the room. Even when I reasonably told her that I was not willing to experiment on my body and my mind with the 60+ different formulations on the market (numerous physical and mental side effects to the Pill), she could not believe that I was would stand up to her and say no.

Sadly, many women never get the chance to say no, and are offered the Pill to "regulate" if they do not want to concieve, and clomid if they do. If it appears to women that these are their only options (and these were the only ones offered to me when I faced infertility), then it's no wonder IVF has become the choice for many women.

Wouldn't it be great if you could treat your PMS/PCOS/PMDD/infertility/anovulation and NOT affect your fertility? That's what makes the Creighton method so awesome. It doesn't look at women as if they are just men with ovaries and a uterus.
3.1.2011 | 2:51am
EVERY child is precious. That is exactly the point. The ones lost in the process are as precious as the ones who survive, so it's hard to justify the expected and intended loss of some of the little ones, by the survival and flourishing of others. The extras can be frozen, but will the couple choose to have those thawed and implanted later, or just discard them? Discarding the extras would also be a moral failure, similar to abortion.
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